POLY-4X ( Oligonol ) Winner of the 2007 Best New Product Award at the 3rd International Conference on Polyphenols and Health (ICPH IFIA/HFE), Nutra Award for Best New Ingredient in 2008 and the Supply Side West Scientific Excellence Award in 2011, Oligonol has been clinically shown to:

Support healthy post-meal blood glucose and lipid levels*[8],[9]

Reduce visceral fat*[10]

Lessen skin wrinkles and brown spots*[11],[12]

Help decrease fatigue and improve endurance*[13],[14]

Because of its effect on circulation, oxidation and inflammation, Oligonol may also support cardiovascular health.*

The polyphenols from lychee fruit and green tea featured in Oligonol:

Increase production of nitric oxide, improving circulation*[15],[16]

Neutralize free radicals*[17]

Reduce UVB-induced COX-2, to protect cell health*[18]

Support healthy levels of inflammatory cytokines*[19]

Inhibit the enzyme collagenase, promoting skin health*[20]

POLY-4X's Oligonol is made from lychee fruit and green tea, both of which have a long history of human consumption. Oligonol has been accepted by the FDA as GRAS and it is Kosher and Halal-certified. Multiple studies on humans and animals have confirmed its safety.*[21],[22],[23],[24],[25]

Fatigue prevention — When more blood is flowing to the muscle, more oxygen is delivered. In the meantime, more waste is being removed from the muscle. This combination prevents fatigue. In one clinical study conducted in a total of 47 young athletes, half the participants took Oligonol, and the other half took regular lychee extract. At the end of the trial, not only did the Oligonol group report feeling improvements in recovery from fatigue, mental clarity, quality of sleep, eye fatigue, and stiff shoulder compared with the regular lychee group, but they also had lower urine levels of 8-OHdG, which is a marker for physical and mental fatigue (Ohno H., et al., 2008).

Heat Stress is experienced by everyone, especially professional athletes, when performing strenuous physical exertion. Heat stress results in increased circulation of excitatory compounds in the blood, contributing to fatigue and muscle soreness, and also wreaks havoc with DNA (Kantidze OL, et al., 2016). In addition, heat stress induces the body’s sweat response, which results in loss of bodily fluids and in turn reduces exercise performance.

Previous studies showed Oligonol could reduce serum concentration of excitatory biomarkers including cortisol, IL-1β, and IL-6 after heat stress (Li S., et al., 1999) and improved exercise performance. One double-blind, crossover clinical study using oral supplementation of 100 mg of Oligonol showed that Oligonol intake before submerging half the body into hot water significantly prevented elevation of tympanic temperature and mean body temperature, when compared with the placebo group. In addition, Oligonol ingestion lowered serum levels of prostaglandin E2 (PGE2) and cyclooxygenase-2 (COX-2) significantly when compared with the placebo group (Shin YO, et al., 2013).

Another placebo-controlled, crossover clinical trial using 200 mg of Oligonol for one week showed a smaller increase in body temperature during heat stress and reduced the amount of whole-body sweat loss. The subjects in the Oligonol group maintained serum aldosterone at a relatively low level and serum sodium at a relatively higher level than the placebo group did (Jeong BL, et al., 2015). These results indicated the important role Oligonol plays in sweating, plasma volume, and osmolality in response to heat stress, suggesting its potential use in attenuating body temperature and excessive sweating under heat load in healthy humans, especially in professional athletes, who are under tremendous heat stress caused by intense training every day. 

[1] Miura T, et al. Edited by Bagchi D, et al. Biotechnology in Functional Foods and Nutraceuticals. Chapter 6, 2010.

[2] KulKarni A, et al. Presented at the International Conference and Exhibition on Nutraceuticals and Functional Food. 2009 (INSFF2009).

[3] Bioequivalence study of Oligonol. Report, Amino Up Chemical Company, Ltd. Japan. 2007 Jun 13.

[4] Hackman R, et al. HHPoPo Polyphenols Communications. 2008;2(T5.79)

[5] Aoyagi K. Presented at the 11th Annual Meeting of the Japanese Society for Complementary and Alternative Medicine. 2008 Nov.

[6] Sakurai T, et al. Bisosci Biotechnol Biochem. 2008;72:463-76.

[7] Lee JB, et al. Nutr Res Practice. 2010; 4(3):203-7.

[8] Nishihira J, et al. Presented at the 4th International Conference on Polyphenols and Health. 2009.

[9] Tani M, et al. Presented at 15th International Symposium on Atherosclerosis. June 2009 (ICPH2009).

[10] Nishihira J, et al. J Funct Foods. 2009;1(4):341-48.

[11] Tsuboi T, et al. Presented at the 16th AHCC Research Association Meeting. 2008 Aug.

[12] Mackenzie R. Presented at Experimental Biology Meeting. 2010 Mar.

[13] Ohno H, et al. Adv Exerc Sports Physiol. 2008; 13(4):93-9.

[14] Shimomura Y, et al. Int J Sports Nutr Exerc Metab. 2010 Jun;20(3):236-44.

[15] Zhang, X, et al. Br J Pharmacol. 2010; 159: 928-938.

[16] Miura T, et al. Biotechnology in Functional Foods and Nutraceuticals. 2010: 91-101.

[17] Aoyagi K, et al. Presented at the 3rd International Conference on Polyphenols and Health. 2007 Nov.

[18] Kundu JK, et al. Photochem Photobiol. 2008;84:399-406.

[19] Lee JB, et al. Nutr Res Practice. 2010; 4(3):203-7.

[20] Tsuboi T, et al. Presented at the 126th Annual Meeting of the Pharmaceutical Society of Japan. 2006 Mar.

[21] Thirunavukkarasu M, et al. Toxicol Mech Methods. 2012; 22(7):555-9.

[22] Fujii H, et al. Food Chem Toxicol. 2008;46:3553-62.

[23] Spierings E, et al. Unpublished study.

[24] Oligonol Unpublished study. Amino Up Chemical Co., Ltd., Japan. 2006 Jul 20.

[25] Kitadate K, et al. Regul Toxicol Pharmacol. 2014; 68: 140-146.