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Brain Support Alcolec® Synapsa® High Impact Formula

Brain Support Alcolec® Synapsa® High Impact Formula

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This Advanced Brain Support Formula Features:

Alpha-Glycerophosphocholine (a-GPC)

Phosphatidylserine (PS)

Synapsa Natural Memory Support is a patented, standardized form of Bacopa monnieri that has been the subject of more than 35 years of clinical study.



a-GPC is essential for healthy cell function, contains no fatty acids and easily passes the blood-brain barrier. Those characteristics make it an excellent carrier for delivery of beneficial nutrients and choline to the brain.

Scientific research has associated GPC itself with tissue growth and renewal, mental focus and recall, and recovery from stroke or circulatory injury.

Nutrition product manufacturers and wholesalers rely on ALC's wide variety of a-GPC products for liquid formulations, dietary supplements, beverages, hard shell capsules, gel caps and capsules. Fractionations range from 50% to pure a-GPC.

Visit our products page for details about each.

Health benefits cited in scientific literature include:

• A vital role in tissue growth and renewal, organ vitality, reproduction and mind-body integration

• Significantly benefits attention, mental focus, recall and cognition

• Benefits that defend against memory decline caused by poor brain circulation or Alzheimer's disease

• Valuable for brain recovery after stroke or circulatory injury

• Can revitalize master hormone functions


PS is a beneficial phospholipid present in all cellular membranes (primarily in their inner layer). More heavily concentrated in the brain and nerves, PS is important to many cellular functions as well as cell structure.

For example, PS helps modulate the activity of receptors, enzymes, ion channels and signaling molecules. For makers of nutritional products, this translates to improved exercise capacity, increased neurotransmitter release in the brain, reversed age-associated nerve cell dendrite loss and increased brain glucose levels.

ALCOLEC® PS products are derived from soy and run no risk of contamination with any kind of prion (protein particles associated with brain diseases). They are available with 20%, 50% and 70% PS compositions.

Health benefits cited in scientific literature include:

• Improved exercise capacity

• Increased neurotransmitter release in the brain

• Reversed age-associated nerve cell dendrite loss

• Increased brain glucose level:
— Improved memory
— Shorter reaction time
— Better hand-eye coordination
— Higher stress resistance
— Mood improvement

FDA qualified health claims for phosphatidylserine (PS):

• Consumption of phosphatidylserine may reduce the risk of dementia in the elderly

• Consumption of phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly


Relevant Studies for the ‘Peak Performance’ Demographic

The patented, standardized Synapsa extract has been the focus of seven ‘foundational’ clinical trials and six ‘targeted’ clinical trials over the last thirty-five years. The most intriguing studies include:

Stough, 2001 showed a statistically significant improvement in speed of visual information processing, learning rate and memory consolidation in subjects 18-60 years of age consuming 300 mg/day Synapsa. A statistically significant reduction in the rate of forgetting was also observed.

Roodenrys, 2002 conducted a randomized, double-blind, placebo-controlled 12-week trial that demonstrated a significant effect of Synapsa (300mg/d) on the retention of new information by participants 40-65 years of age.

Stough, 2008 conducted a randomized double-blind, placebo-controlled 90-day study with 62 participants, ages 18-60, consuming 300 mg/day. Synapsa showed a statistically significant improvement in working memory, visual information processing (sustained attention) and accuracy in complex cognitive tasks.

Downey, 2012 studied two different doses (320 mg/640 mg) in a study on sustained cognitive performance, examining the acute (short term) effect of Synapsa in healthy adult subjects. Significantly improved performance was seen in faster information processing and improved decision-making time in a multitasking environment.

The Synapsa Claims Dossier

To support commercialization efforts for our Synapsa Natural Memory Support ingredient, PLT has developed a comprehensive claims dossier in conjunction with a third-party reviewer focused on claims support and scientific communications to provide an impartial review of the validity of the science supporting Synapsa claims.

The Synapsa Claims Dossier includes a comprehensive list of potential/proposed claims, a legal executive summary and in-depth reviews of how the claims can be supported by the data. In the case of Synapsa, these include ‘chronic’ claims – that cover long-term use of the ingredient, ‘acute’ claims that are based around short-term, experiential use of the ingredient and general claims in the area of cognitive health. The Comprehensive List of Claims in the new dossier includes in-depth reviews on supporting 19 different potential claims for consumer products that contain or feature Synapsa

Two types of use supported by studies

Studies show support for two distinct types of benefit from Synapsa Natural Memory Support: daily, long-term use (chronic) to enhance learning and memory, and short-term use (acute) to improve mental performance in cognitively demanding environments such as test-taking. In addition, the majority of studies behind Synapsa have been conducted on healthy adult subjects between 18-65. From a market standpoint, in the United States today, more than 120 million people are considered knowledge workers who use cognitive skills as a daily part of their jobs. In addition, recent estimates of college students range upwards of 21 million. Both groups are good targets for new formulations based on Synapsa, along with any consumers looking for support for learning, memory and mental performance.</p>

What is Synapsa?

Synapsa Natural Memory Support is a unique, standardized extract of Bacopa monnieri, with a wide range of active constituents that contribute to its therapeutic properties. Bacopa monnieri (also known as brahmi) is an herb that has been used in traditional Ayurvedic medicine for centuries.

Today’s proprietary Synapsa ingredient is based on a patented extraction process that follows an exacting farming and manufacturing process to ensure a standardized level of quality – since each step of this process can influence the final product’s complex phytochemical profile and therapeutic action. Putting farming & manufacturing controls in place across each step allows for consistency of the entire product & results in a product that can be clinically studied


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