An advanced bone formula with calcium and vitamin D per capsule for added bone support Advanced Bone Support contains more calcium, magnesium, and vitamin D per capsule than the previous formula. In addition, it provides B vitamins for healthy methylation, and boron – all to support bone health. Although everyone loses bone density as they age, certain groups are particularly at risk. As many as half of all women in the United States older than 65 should be concerned about maintaining good bone health. Thorne's Advanced Bone Support is a comprehensive bone support supplement.* It contains dicalcium malate and dimagnesium malate (two calcium or magnesium molecules each bound to one molecule of malic acid) for enhanced absorption and greater concentration of these important minerals.* Adequate magnesium intake promotes bone density by optimizing the secretion of parathyroid hormone and facilitating active calcium transport to the bones.* Advanced Bone Support provides vitamin D3, which facilitates the absorption of calcium; boron, which assists the body's metabolism of vitamin D and estrogen; and B vitamins for healthy methylation, which mediates homocysteine levels, a known risk factor of low bone density.* Research indicates that an elevated homocysteine level in the blood can interfere with the integrity of the bone matrix. Therefore, Advanced Bone Support contains methylcobalamin (an active form of vitamin B12), L-5-methyltetrahydrofolate (the active form of folic acid), and pyridoxal 5'-phosphate (the active form of vitamin B6) for their function in helping to maintain already normal homocysteine levels.* To provide a bone health formula that can be used by individuals taking a blood-thinning medication, Advanced Bone Support does not contain vitamin K. As women age, they experience an overall increase in bone loss compared to bone formation, so a woman's concern about maintaining good bone health should begin well before menopause. Because some bone loss during menopause is inevitable, more bone a woman has "banked" earlier in life, the greater her peak bone mass as she begins to age. Hence, menopausal bone loss will have less of an adverse impact. Even women in the 18-35 year-old age group should make an effort to achieve good bone health, because physical inactivity, low body weight, eating disorders, and poor nutrition during these ages can have adverse impacts on bone health later in life. Groups at particular risk for bone loss in addition to women include smokers, those with a sedentary lifestyle, individuals who consume excessive sugar, alcohol, or caffeine, small-boned individuals, Caucasians, Asians, and patients on steroid or anticonvulsant therapies for prolonged periods of time. Suggested Usage: Take 2 capsules two times daily or as recommended by your health-care practitioner.

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Supports cognitive function and healthy nerve sensations in the hands and feet Acetyl-L-Carnitine enhances neurotransmitter regulation, which can support optimal nerve function. Thorne's Acetyl-L-Carnitine supports the health of the nerves in the upper and lower limbs and enhances the production of the neurotransmitter acetylcholine, which supports brain function.* Acetyl-L-carnitine also helps minimize the discomfort due to alterations in nerve function; for example, in cancer patients undergoing chemotherapy or individual with high blood sugar.* Acetyl-L-carnitine is better absorbed and crosses the blood-brain barrier more rapidly than L-carnitine.* Studies have demonstrated its effectiveness in supporting cognitive health and maintaining a positive mood in the elderly, possibly by partially inhibiting the activity of the hypothalamic-pituitary-adrenal axis and lowering chronically elevated cortisol levels, which become elevated during stress.* In addition to acetyl-L-carnitine's support of brain and nerve health, it also promotes healthy sperm count and motility.* This product has been third-party tested and certified to verify what's in the package matches what's on the label and to confirm it contains no unsafe levels of contaminants, such as heavy metals, pesticides, and microorganisms. Suggested Usage: Take 1 capsule two to three times daily or as recommended by your health-care practitioner.  

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Support heart health, fetal development, nervous system, and mood with 5-MTHF 5-MTHF is a bioactive, methylated form of folate, an essential B vitamin that supports heart, brain, blood, and bone health and is suitable for individuals with MTFHR gene mutations. Folate is a key component in the body’s methylation cycle, a series of biochemical reactions that play a beneficial role in multiple body systems. Heart and brain health, cellular energy production, fat metabolism, liver detoxification, and bone health all rely on a healthy methylation cycle. Approximately 60 percent of U.S. adults have a genetic variation that makes it difficult for their methylation cycle to function optimally. For these individuals, methylated vitamins, like Thorne’s 5-MTHF, provide essential nutritional support.* Benefits of Thorne’s 5-MTHF: Nutritional support for individuals who have an MTHFR gene mutation* Supports production of key neurotransmitters – serotonin, melatonin, dopamine, and epinephrine – natural brain chemicals that play an important role in regulating brain function and mood* Promotes cardiovascular, brain, and bone health by maintaining a healthy methylation cycle and a normal homocysteine level* Supports healthy fetal brain and spinal cord development* Promotes blood and nerve cell health* Features of Thorne's 5-MTHF: Suitable for individuals who have an MTHFR gene mutation* Active, methylated folate (5-MTHF) means your body gets the highest benefit with the least additional work 1 mg 5-MTHF is recommended for support of fetal development during pregnancy* Easy-to-take, small capsules Suggested Usage: Take 1 capsule one to three times daily or as recommended by your health-care practitioner.

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Enhances sleep and helps manage stress 5-HTP increases serotonin levels to promote restful sleep, manage stress, and decrease sugar cravings. It contains pyridoxal 5'-phosphate, the active form of vitamin B6 and the necessary cofactor for the conversion of 5-HTP to serotonin. The serotonin levels in the body are associated with the regulation of sleep, mood, and appetite. A balanced serotonin level has been shown to support restful sleep, good mood, and decreased sugar cravings.* There are several ways to support a healthy serotonin level. L-tryptophan and 5-Hydroxytryptophan (5-HTP) are both precursors to serotonin. However, supplementation with 5-HTP is preferable, because unlike L-tryptophan, 5-HTP cannot be shunted into other uses in the body, such as niacin or protein production. 5-HTP is well absorbed by the body and easily crosses the blood-brain barrier where it can increase the synthesis of serotonin in the central nervous system.* And 5-HTP can be taken with meals without reducing its effectiveness.* 5-Hydroxytryptophan (5-HTP) is the intermediate metabolite the body produces when it initiates the process of converting the essential amino acid L-tryptophan to serotonin. Therefore, supplementation with 5-HTP will bypass the conversion of L-tryptophan into 5-HTP by the enzyme tryptophan hydroxylase – which is the rate-limiting step in the synthesis of serotonin – and is a conversion that can be inhibited by a number of factors, including stress, insulin resistance, increasing age, and deficiencies of vitamin C, folate, and iron.* 5-HTP is well absorbed when taken orally, with about 70 percent going into the bloodstream.* Intestinal absorption of 5-HTP does not require the presence of a transport molecule, and its absorption is not affected by the presence of other amino acids; therefore, 5-HTP can be taken with meals without reducing its effectiveness. 5-HTP has been shown to have a beneficial impact on mood, sleep, carbohydrate cravings, and discomfort associated with fatigue.* Numerous studies of individuals with negative mood status have shown significant positive response with 50-300 mg of 5-HTP daily.* To further facilitate serotonin production, Thorne's 5-HTP formula contains pyridoxal 5'-phosphate, the active form of vitamin B6 and the necessary cofactor for the conversion of 5-HTP to serotonin. 5-HTP is commercially produced by extraction from the seeds of the African plant, Griffonia simplicifolia. Each lot is thoroughly tested for contaminants, including Peak X, and is Peak X free. Suggested Usage: Take 1-2 capsules three times daily or as recommended by your health-care practitioner.

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