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AlchePharma International ®
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Why This "Rare Sugar" Outperforms Oral Semaglutide Ep. 1283 MAR 2026
Academic Summary: This study compared the metabolic and neural effects of D-Allulose and oral semaglutide in diet-induced obese mice. Both substances significantly reduced food intake and body weight in the early stages by activating anorexigenic (leptin-responsive) neurons in the arcuate nucleus of the hypothalamus. However, D-Allulose uniquely inhibited orexigenic (hunger-stimulating, ghrelin-responsive) neurons and utilized a combined vagal afferent and central nervous route. This allowed for persistent weight loss even after the treatment was discontinued, whereas semaglutide-treated subjects experienced a weight rebound. Additionally, both treatments equally elevated grip strength.
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