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We review the new research in regard to the phenomenal strength gains of post menopausal females who took Vitamin D for 9 months.

* Effect of vitamin D supplementation alone on muscle function in postmenopausal women: a randomized, double-blind, placebo-controlled clinical trial.

Osteoporosis Int. 2015 Oct;26(10):2413-21. doi: 10.1007/s00198-015-3151-9. Epub 2015 May 9

Those in the intervention group who took the supplements had a lower recurrence rate for vertigo episodes after an average of one year than those in the observation group. People taking supplements had an average recurrence rate of 0.83 times per person-year, compared to 1.10 times per person-year for those in the observation group, or a 24% reduction in the annual recurrence rate.

#vertigo #bppv #vitamind

Seong-Hae Jeong, Ji-Soo Kim, Hyo-Jung Kim, Jeong-Yoon Choi, Ja-Won Koo, Kwang-Dong Choi, Ji-Yun Park, Seung-Han Lee, Seo-Young Choi, Sun-Young Oh, Tae-Ho Yang, Jae Han Park, Ileok Jung, Soyeon Ahn, Sooyeon Kim. Prevention of Benign Paroxysmal Positional Vertigo with Vit D Supplementation: A Randomized Trial. Neurology, 2020; DOI: 10.1212/WNL.0000000000010343

Researchers witness a 10.4% reduction in arterial stiffness in just 16 weeks with high dose oral vitamin D.

Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial. PLOS ONE, 2017; 12 (12): e0188424 DOI: 10.1371/journal.pone.0188424

7,000 IUs/daily of Vitamin D needed claim researchers

- The recommended intake of vitamin D specified by the IOM is 600 IU/day through age 70 years, and 800 IU/day for older ages. "Calculations by us and other researchers have shown that these doses are only about one-tenth those needed to cut incidence of diseases related to vitamin D deficiency,"

- "We call for the NAS-IOM and all public health authorities concerned with transmitting accurate nutritional information to the public to designate, as the RDA, a value of approximately 7,000 IU/day from all sources."

* A Statistical Error in the Estimation of the Recommended Dietary Allowance for Vitamin D Nutrients 2014, 6(10), 4472-4475; doi:10.3390/nu6104472

High Vitamin D Levels associated with an 82% reduction in Breast Cancer Incidence

"We found that participants with blood levels of 25(OH)D that were above 60 ng/ml had one-fifth the risk of breast cancer compared to those with less than 20 ng/ml," said principal investigator and co-author Cedric F. Garland, DrPH, adjunct professor in the UC San Diego Department of Family Medicine and Public Health. Risk of cancer appeared to decline with greater levels of serum vitamin D.

Breast cancer risk markedly lower with serum 25-hydroxyvitamin D concentrations 60 vs 20 ng/ml (150 vs 50 nmol/L): Pooled analysis of two randomized trials and a prospective cohort McDonnell SL, Baggerly CA, French CB, Baggerly LL, Garland CF, et al. (2018) Breast cancer risk markedly lower with serum 25-hydroxyvitamin D concentrations 60 vs 20 ng/ml (150 vs 50 nmol/L): Pooled analysis of two randomized trials and a prospective cohort. PLOS ONE 13(6): e0199265.

A review published in The Journal of the American Osteopathic Association found Vitamin D can't be metabolized without sufficient magnesium levels, meaning Vitamin D remains stored and inactive for as many as 50 percent of Americans

Citation: Role of Magnesium in Vitamin D Activation and Function, The Journal of the American Osteopathic Association, March 2018, Vol. 118, 181-189. doi:10.7556/jaoa.2018.037

Vitamin D reduces lung disease flare-ups by over 40 percent

- Patients with a vitamin D deficiency benefited dramatically from taking the supplements but the striking reduction in flare-ups was not seen among patients who had a higher vitamin D status at the start of the trial. However, researchers did find vitamin D supplementation modestly reduced the severity and duration of flare-up symptoms in all patients in the vitamin D group, regardless of their baseline vitamin D levels, compared to the placebo group.

* Published in the journal Lancet Respiratory Medicine DEC 2014

We review the the study "Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data" by the BMJ in regard to the amount of  vitamin D needed to prevent colds and flu on a daily basis.

In conclusion, we found significant relationships between vitamin D levels and the number COVID–19 cases and especially the mortality caused by this infection. The most vulnerable group of population for COVID–19 is also the one that has the most deficit in Vitamin D

The role of Vitamin D in the prevention of Coronavirus Disease 2019 infection and mortality DOI:10.21203/rs.3.rs-21211/v1

We review the research " Association between vitamin D deficiency and heart failure risk in the elderly " in which they reported a 12.2 times increased risk of heart failure among those with low Vitamin D levels.

Vitamin D supplements protect against severe asthma attacks. We look at the meta-analysis conducted by the Lancet which showed the possible benefits of oral vitamin D supplementation reducing the likelihood of a severe asthma attack.

Citation: Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data DOI:10.1016/S2213-2600(17)30306-5

Study: Link between vitamin D and dementia risk confirmed

- The study found that people with low levels of vitamin D had a 53-percent increased risk of developing dementia and those who were severely deficient had a 125-percent increased risk compared to participants with normal levels of vitamin D.

People with lower levels of vitamin D were nearly 70 percent more likely to develop Alzheimer's disease and those who had severe deficiency were over 120 percent more likely to develop the disease.

* August 6, 2014, online issue of Neurology

We review the study " Widespread vitamin D deficiency likely due to sunscreen use, increase of chronic diseases, review finds " in regard to sunscreen being associated with mass vitamin D deficiencies.

Citation: Vitamin D Deficiency, Its Role in Health and Disease, and Current Supplementation Recommendations. The Journal of the American Osteopathic Association, 2017; 117 (5): 301 DOI: 10.7556/jaoa.2017.055

Omega-3 fatty acids, vitamin D may control brain serotonin, affecting behavior and psychiatric disorders

- Many clinical disorders, such as autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), bipolar disorder, schizophrenia, and depression share as a unifying attribute low brain serotonin. "In this paper we explain how serotonin is a critical modulator of executive function, impulse control, sensory gating, and pro-social behavior," says Dr. Patrick. "We link serotonin production and function to vitamin D and omega-3 fatty acids, suggesting one way these important micronutrients help the brain function and affect the way we behave."

- Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar, schizophrenia, and impulsive behavior Published online before print February 24, 2015, doi: 10.1096/fj.14-268342

"We know that Vitamin C consumption is linked with skeletal muscle mass. It helps defend the cells and tissues that make up the body from potentially harmful free radical substances. Unopposed these free radicals can contribute to the destruction of muscle, thus speeding up age-related decline."

Lucy N Lewis, Richard P G Hayhoe, Angela A Mulligan, Robert N Luben, Kay-Tee Khaw, Ailsa A Welch. Lower Dietary and Circulating Vitamin C in Middle- and Older-Aged Men and Women Are Associated with Lower Estimated Skeletal Muscle Mass. The Journal of Nutrition, 2020; DOI: 10.1093/jn/nxaa221

How vitamin C kills cancer cells

We review the recent study " Why high-dose vitamin C kills cancer cells " in regard to intravenous ascorbate effectively limiting pancreatic cancer growth in animal models

Vitamin C fights cancer in an unusual way

We discuss the recent study of how Vitamin C fights cancer in a most unexpected way. ( Please bear with me, this video is slightly technical ).

Vitamin C stresses and kills mutant cancer cells

AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE

Relevant Citations:

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH Science DOI: 10.1126/science.aaa5004

How Much Vitamin C to help with Cataracts

We review the Twin study " Increased vitamin C in the diet could help protect against cataracts ".

* Citation Title : Genetic and Dietary Factors Influencing the Progression of Nuclear Cataract

"Our first in vitro experiment showed remarkable effects," said Longo. "When used alone, fasting-mimicking diet or vitamin C alone reduced cancer cell growth and caused a minor increase in cancer cell death. But when used together, they had a dramatic effect, killing almost all cancerous cells."

Maira Di Tano, Franca Raucci, Claudio Vernieri, Irene Caffa, Roberta Buono, Maura Fanti, Sebastian Brandhorst, Giuseppe Curigliano, Alessio Nencioni, Filippo de Braud, Valter D. Longo. Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers. Nature Communications, 2020; 11 (1) DOI: 10.1038/s41467-020-16243-3

Many of those most at risk from COVID-19, including individuals who are older, Black, male and with chronic medical conditions like osteoarthritis, hypertension and diabetes, tend to have lower levels of vitamin C, another reason vitamin C therapy would be considered a reasonable treatment, Isales says. The investigators also note that patients may develop a vitamin C deficiency over the course of their COVID-19 illness since, during an active infection, vitamin C is consumed at a more rapid rate. Insufficient levels can augment the damage done by an overzealous immune response

MATHS+ :

Disclaimer: The information provided in this protocol is primarily to provide information to physicians on a protocol that we found to be highly effective in damping down the hyperinflammatory cytokine “storm” that is the cause of mortality and morbidity in COVID-19. Our guidance should only be used by medical professionals in formulating their approach to COVID19. Patients should always consult with their physician before starting any medical treatment.

Gregory Patterson, Carlos M. Isales, Sadanand Fulzele. Low level of Vitamin C and dysregulation of Vitamin C transporter might be involved in the severity of COVID-19 Infection. Aging and Disease, 2020; DOI: 10.14336/AD.2020.0918

Hujoel's literature review also determined that "retinal hemorrhaging and cerebral strokes are associated with increased gingival bleeding tendency, and that (vitamin C) supplementation reverses the retinal bleeding associated with low (vitamin C) plasma levels."

Philippe P Hujoel, Tomotaka Kato, Isabel A Hujoel, Margaux L A Hujoel. Bleeding tendency and ascorbic acid requirements: systematic review and meta-analysis of clinical trials. Nutrition Reviews, 2021; DOI: 10.1093/nutrit/nuaa115

Researchers discovered that intravenous vitamin C therapy reduced mortality in septic patients from 46% in the placebo group to almost 30% in the vitamin C group at day 28.

On average, the vitamin C group spent three fewer days in the ICU (seven days compared to 10) at day 28 and a week less in the hospital overall (15 days versus 22) by day 60 than the placebo group.

Alpha A. Fowler, Jonathon D. Truwit, R. Duncan Hite, Peter E. Morris, Christine DeWilde, Anna Priday, Bernard Fisher, Leroy R. Thacker, Ramesh Natarajan, Donald F. Brophy, Robin Sculthorpe, Rahul Nanchal, Aamer Syed, Jamie Sturgill, Greg S. Martin, Jonathan Sevransky, Markos Kashiouris, Stella Hamman, Katherine F. Egan, Andrei Hastings, Wendy Spencer, Shawnda Tench, Omar Mehkri, James Bindas, Abhijit Duggal, Jeanette Graf, Stephanie Zellner, Lynda Yanny, Catherine McPolin, Tonya Hollrith, David Kramer, Charles Ojielo, Tessa Damm, Evan Cassity, Aleksandra Wieliczko, Matthew Halquist. Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure. JAMA, 2019; 322 (13): 1261 DOI: 10.1001/jama.2019.11825

Vitamin C rapidly improves emotional state of acutely hospitalized patients

- Vitamin C provided for a mean of 8.2 d increased plasma vitamin C concentrations to normal  and was associated with a 71% reduction in mood disturbance  and a 51% reduction in psychological distress .

* This trial was registered at clinicaltrials.gov as NCT01630720.

We review the research " Larger doses of vitamin C may lead to a greater reduction in common cold duration and infections" in regard to Vitamin C placebo control studies primarily showing benefit at 3 grams or more.

Citation: Vitamin C and Infections. Nutrients, 2017; 9 (4): 339 DOI: 10.3390/nu9040339

We review actually two separate studies on Vitamin C and cancer that were released within the same week " Vitamin C may encourage blood cancer stem cells to die ", and "CRI scientists discover vitamin C regulates stem cell function, curbs leukemia development " both focusing on the TET2 enzyme in regard to Stem Cells.

Citations: Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression. Cell, 2017; DOI: 10.1016/j.cell.2017.07.032 / Ascorbate regulates haematopoietic stem cell function and leukaemogenesis Nature (2017) doi:10.1038/nature23876

Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

All of the six oral administration trials used vitamin C doses of 1 to 3 g/day. Overall, in these low dose oral administration studies, vitamin C reduced the length of ICU stay by 8.6%

Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis Nutrients 2019, 11(4), 708; doi: 10.3390/nu11040708

Scientists figure out how vitamin E keeps muscles healthy

Vitamin E has long known as a powerful antioxidant, and now scientists have shown that without it, the plasma membrane, which essentially keeps a cell from spilling its contents and controls what moves in and out, cannot properly heal.

The scientist suspects knowing the cell membrane repair action of vitamin E has implications for muscular dystrophy, and common diabetes-related muscle weakness, as well as traumatic brain injury, resulting from collisions on a football field, battlefield, or roadway. With a traumatic brain injury, for example, one of the first events that happens is that the plasma membrane of the neurons, key cells in the central nervous system, tear.

"Part of how we build muscle is a more natural tearing and repair process -- that is the no pain, no gain portion -- but if that repair doesn't occur, what you get is muscle cell death. If that occurs over a long period of time, what you get is muscle-wasting disease,"

"This means, for the first time, 83 years after its initial discovery, we know what the cellular function of vitamin E is, and knowing that cellular function, we can now ask whether we can apply that knowledge to medically relevant areas," McNeil said.

The antioxidant requirement for plasma membrane repair in skeletal muscle. Free Radical Biology and Medicine, 2015; 84: 246 DOI: 10.1016/j.freeradbiomed.2015.03.016

Vitamin E results in a 49% reduced risk of cardiovascular death

Optimal dose of vitamin E maximizes benefits, minimizes risk

* published in the November 2008 issue of Nutrition Reviews

- One of the most compelling studies of the benefits of vitamin E is the Women's Health Study, in which 40,000 healthy women, 45 and older, took 600 IU vitamin E supplements or a placebo every other day for 10 years. Women taking the supplements had 24 percent fewer deaths from heart disease. Vitamin E's protective effect appeared even stronger in women 65 and older. Those taking the vitamin experienced a 26 percent reduction in cardiovascular events and a 49 percent reduction in cardiovascular deaths.

Vitamin E intake critical during ‘the first 1,000 days’

**Watch in HD**

- “surveys show that 90 percent of men and 96 percent of women don’t consume the amount currently recommended”

* Published in Advances in Nutrition Sep 2014

Compared to the mice that had normal amounts of vitamin E in their diet, the mice fed extra vitamin E had:

• 1,000 times fewer bacteria in their lungs
• Two times fewer the number of white blood cells (neutrophils)

The reduced numbers of bacteria and white blood cells resulted in less lung damage in the older mice who received extra vitamin E. These mice were able to control the infection as efficiently as young mice.

* Published online before print December 15, 2014, doi: 10.4049/​jimmunol.1402401

Study results showed that lower levels of serum albumin and four dietary antioxidants - vitamins A, B2, E, and folate -- were associated with a higher risk of HR-HPV infection. Albumin is the most bountiful circulating protein in plasma, and decreased serum albumin was found to be associated with increased systemic inflammation and impaired immune response. Based on the four dietary antioxidants, the researchers developed a nutritional antioxidant score.

#HPV #Antioxidants #infection

Hui-Yi Lin, Qiufan Fu, Yu-Hsiang Kao, Tung-sung Tseng, Krzysztof Reiss, Jennifer E Cameron, Martin J Ronis, Joseph Su, Navya Nair, Hsiao-Man Chang, Michael E Hagensee, Antioxidants Associated with Oncogenic HPV Infection in women, The Journal of Infectious Diseases, 2021;, jiab148, https://doi.org/10.1093/infdis/jiab148

HPV, antioxidants, infection, vitamin a, riboflavin, vitamin e, folate, folic acid, dietary antioxidants, carcinogenesis, HR-HPV, serum albumin, cancer, plasma, oncogenic, NHNES, human papillomavirus