Hujoel's literature review also determined that "retinal hemorrhaging and cerebral strokes are associated with increased gingival bleeding tendency, and that (vitamin C) supplementation reverses the retinal bleeding associated with low (vitamin C) plasma levels."

Philippe P Hujoel, Tomotaka Kato, Isabel A Hujoel, Margaux L A Hujoel. Bleeding tendency and ascorbic acid requirements: systematic review and meta-analysis of clinical trials. Nutrition Reviews, 2021; DOI: 10.1093/nutrit/nuaa115

Researchers discovered that intravenous vitamin C therapy reduced mortality in septic patients from 46% in the placebo group to almost 30% in the vitamin C group at day 28.

On average, the vitamin C group spent three fewer days in the ICU (seven days compared to 10) at day 28 and a week less in the hospital overall (15 days versus 22) by day 60 than the placebo group.

Alpha A. Fowler, Jonathon D. Truwit, R. Duncan Hite, Peter E. Morris, Christine DeWilde, Anna Priday, Bernard Fisher, Leroy R. Thacker, Ramesh Natarajan, Donald F. Brophy, Robin Sculthorpe, Rahul Nanchal, Aamer Syed, Jamie Sturgill, Greg S. Martin, Jonathan Sevransky, Markos Kashiouris, Stella Hamman, Katherine F. Egan, Andrei Hastings, Wendy Spencer, Shawnda Tench, Omar Mehkri, James Bindas, Abhijit Duggal, Jeanette Graf, Stephanie Zellner, Lynda Yanny, Catherine McPolin, Tonya Hollrith, David Kramer, Charles Ojielo, Tessa Damm, Evan Cassity, Aleksandra Wieliczko, Matthew Halquist. Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure. JAMA, 2019; 322 (13): 1261 DOI: 10.1001/jama.2019.11825

Vitamin C rapidly improves emotional state of acutely hospitalized patients

- Vitamin C provided for a mean of 8.2 d increased plasma vitamin C concentrations to normal  and was associated with a 71% reduction in mood disturbance  and a 51% reduction in psychological distress .

* This trial was registered at clinicaltrials.gov as NCT01630720.

We review the research " Larger doses of vitamin C may lead to a greater reduction in common cold duration and infections" in regard to Vitamin C placebo control studies primarily showing benefit at 3 grams or more.

Citation: Vitamin C and Infections. Nutrients, 2017; 9 (4): 339 DOI: 10.3390/nu9040339

We review actually two separate studies on Vitamin C and cancer that were released within the same week " Vitamin C may encourage blood cancer stem cells to die ", and "CRI scientists discover vitamin C regulates stem cell function, curbs leukemia development " both focusing on the TET2 enzyme in regard to Stem Cells.

Citations: Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression. Cell, 2017; DOI: 10.1016/j.cell.2017.07.032 / Ascorbate regulates haematopoietic stem cell function and leukaemogenesis Nature (2017) doi:10.1038/nature23876

Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

All of the six oral administration trials used vitamin C doses of 1 to 3 g/day. Overall, in these low dose oral administration studies, vitamin C reduced the length of ICU stay by 8.6%

Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis Nutrients 2019, 11(4), 708; doi: 10.3390/nu11040708

"We know that Vitamin C consumption is linked with skeletal muscle mass. It helps defend the cells and tissues that make up the body from potentially harmful free radical substances. Unopposed these free radicals can contribute to the destruction of muscle, thus speeding up age-related decline."

Lucy N Lewis, Richard P G Hayhoe, Angela A Mulligan, Robert N Luben, Kay-Tee Khaw, Ailsa A Welch. Lower Dietary and Circulating Vitamin C in Middle- and Older-Aged Men and Women Are Associated with Lower Estimated Skeletal Muscle Mass. The Journal of Nutrition, 2020; DOI: 10.1093/jn/nxaa221

How vitamin C kills cancer cells

We review the recent study " Why high-dose vitamin C kills cancer cells " in regard to intravenous ascorbate effectively limiting pancreatic cancer growth in animal models

Vitamin C fights cancer in an unusual way

We discuss the recent study of how Vitamin C fights cancer in a most unexpected way. ( Please bear with me, this video is slightly technical ).

Vitamin C stresses and kills mutant cancer cells

AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE

Relevant Citations:

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH Science DOI: 10.1126/science.aaa5004

How Much Vitamin C to help with Cataracts

We review the Twin study " Increased vitamin C in the diet could help protect against cataracts ".

* Citation Title : Genetic and Dietary Factors Influencing the Progression of Nuclear Cataract

"Our first in vitro experiment showed remarkable effects," said Longo. "When used alone, fasting-mimicking diet or vitamin C alone reduced cancer cell growth and caused a minor increase in cancer cell death. But when used together, they had a dramatic effect, killing almost all cancerous cells."

Maira Di Tano, Franca Raucci, Claudio Vernieri, Irene Caffa, Roberta Buono, Maura Fanti, Sebastian Brandhorst, Giuseppe Curigliano, Alessio Nencioni, Filippo de Braud, Valter D. Longo. Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers. Nature Communications, 2020; 11 (1) DOI: 10.1038/s41467-020-16243-3

Many of those most at risk from COVID-19, including individuals who are older, Black, male and with chronic medical conditions like osteoarthritis, hypertension and diabetes, tend to have lower levels of vitamin C, another reason vitamin C therapy would be considered a reasonable treatment, Isales says. The investigators also note that patients may develop a vitamin C deficiency over the course of their COVID-19 illness since, during an active infection, vitamin C is consumed at a more rapid rate. Insufficient levels can augment the damage done by an overzealous immune response

MATHS+ :

Disclaimer: The information provided in this protocol is primarily to provide information to physicians on a protocol that we found to be highly effective in damping down the hyperinflammatory cytokine “storm” that is the cause of mortality and morbidity in COVID-19. Our guidance should only be used by medical professionals in formulating their approach to COVID19. Patients should always consult with their physician before starting any medical treatment.

Gregory Patterson, Carlos M. Isales, Sadanand Fulzele. Low level of Vitamin C and dysregulation of Vitamin C transporter might be involved in the severity of COVID-19 Infection. Aging and Disease, 2020; DOI: 10.14336/AD.2020.0918