Vitamin K is found in two primary forms: Vitamin K1 (phylloquinone) and Vitamin K2 (menaquinone). There are a few different menquinones such as menaquinone 4 and menaquinone 7. The main difference between these forms is that K2 as menaquinone 7 is absorbed at a much higher rate than K1 and remains in the body 36 times longer (allowing it to move beyond the liver into other tissues); whereas K1 is primarily utilized by the liver to make blood clotting factors. In addition to other roles, Vitamin K2 (menaquinone-7) is essential for healthy, strong bones and for supporting arterial health.*
Features:
Menaquinone-7 is the most efficacious form of Vitamin K for bone and cardio health.
The 45 mcg dosage is the recommendation of leading vitamin K2 researchers. This dosage was also the highest consumption level of the patients in the landmark Rotterdam study: 50% reduction in deaths from cardiovascular disease.*
Menaquinone-7 is made from an all-natural food source (fermented soy).
It is vegetarian (including capsule).
Benefits:
Vitamin K2 helps activate (turn-on) osteocalcin.*
Osteocalcin helps to build new bone matrix by aiding the binding of calcium.
Vitamin K2 is important in the maintenance of bone mineral content and bone strength.*
Vitamin K2 helps activate (turn-on) MGP, which is responsible for regulating the amount of calcium that accumulates in arterial walls.*
Vitamin K2 supports the integrity of arterial walls through the regulation of calcium in the body.*
Vitamin K2 helps support the health and elasticity of arterial walls.*
Suggested Use: Adults take one (1) vegetarian capsule daily at mealtime, or as directed by a health care professional.
We review the new research in regard to the phenomenal strength gains of post menopausal females who took Vitamin D for 9 months.
* Effect of vitamin D supplementation alone on muscle function in postmenopausal women: a randomized, double-blind, placebo-controlled clinical trial.
Osteoporosis Int. 2015 Oct;26(10):2413-21. doi: 10.1007/s00198-015-3151-9. Epub 2015 May 9
Those in the intervention group who took the supplements had a lower recurrence rate for vertigo episodes after an average of one year than those in the observation group. People taking supplements had an average recurrence rate of 0.83 times per person-year, compared to 1.10 times per person-year for those in the observation group, or a 24% reduction in the annual recurrence rate.
#vertigo #bppv #vitamind
Seong-Hae Jeong, Ji-Soo Kim, Hyo-Jung Kim, Jeong-Yoon Choi, Ja-Won Koo, Kwang-Dong Choi, Ji-Yun Park, Seung-Han Lee, Seo-Young Choi, Sun-Young Oh, Tae-Ho Yang, Jae Han Park, Ileok Jung, Soyeon Ahn, Sooyeon Kim. Prevention of Benign Paroxysmal Positional Vertigo with Vit D Supplementation: A Randomized Trial. Neurology, 2020; DOI: 10.1212/WNL.0000000000010343
Researchers witness a 10.4% reduction in arterial stiffness in just 16 weeks with high dose oral vitamin D.
Dose responses of vitamin D3 supplementation on arterial stiffness in overweight African Americans with vitamin D deficiency: A placebo controlled randomized trial. PLOS ONE, 2017; 12 (12): e0188424 DOI: 10.1371/journal.pone.0188424
7,000 IUs/daily of Vitamin D needed claim researchers
- The recommended intake of vitamin D specified by the IOM is 600 IU/day through age 70 years, and 800 IU/day for older ages. "Calculations by us and other researchers have shown that these doses are only about one-tenth those needed to cut incidence of diseases related to vitamin D deficiency,"
- "We call for the NAS-IOM and all public health authorities concerned with transmitting accurate nutritional information to the public to designate, as the RDA, a value of approximately 7,000 IU/day from all sources."
* A Statistical Error in the Estimation of the Recommended Dietary Allowance for Vitamin D Nutrients 2014, 6(10), 4472-4475; doi:10.3390/nu6104472
High Vitamin D Levels associated with an 82% reduction in Breast Cancer Incidence
"We found that participants with blood levels of 25(OH)D that were above 60 ng/ml had one-fifth the risk of breast cancer compared to those with less than 20 ng/ml," said principal investigator and co-author Cedric F. Garland, DrPH, adjunct professor in the UC San Diego Department of Family Medicine and Public Health. Risk of cancer appeared to decline with greater levels of serum vitamin D.
Breast cancer risk markedly lower with serum 25-hydroxyvitamin D concentrations 60 vs 20 ng/ml (150 vs 50 nmol/L): Pooled analysis of two randomized trials and a prospective cohort McDonnell SL, Baggerly CA, French CB, Baggerly LL, Garland CF, et al. (2018) Breast cancer risk markedly lower with serum 25-hydroxyvitamin D concentrations 60 vs 20 ng/ml (150 vs 50 nmol/L): Pooled analysis of two randomized trials and a prospective cohort. PLOS ONE 13(6): e0199265.
A review published in The Journal of the American Osteopathic Association found Vitamin D can't be metabolized without sufficient magnesium levels, meaning Vitamin D remains stored and inactive for as many as 50 percent of Americans
Citation: Role of Magnesium in Vitamin D Activation and Function, The Journal of the American Osteopathic Association, March 2018, Vol. 118, 181-189. doi:10.7556/jaoa.2018.037
Vitamin D reduces lung disease flare-ups by over 40 percent
- Patients with a vitamin D deficiency benefited dramatically from taking the supplements but the striking reduction in flare-ups was not seen among patients who had a higher vitamin D status at the start of the trial. However, researchers did find vitamin D supplementation modestly reduced the severity and duration of flare-up symptoms in all patients in the vitamin D group, regardless of their baseline vitamin D levels, compared to the placebo group.
* Published in the journal Lancet Respiratory Medicine DEC 2014
We review the the study "Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data" by the BMJ in regard to the amount of vitamin D needed to prevent colds and flu on a daily basis.
In conclusion, we found significant relationships between vitamin D levels and the number COVID–19 cases and especially the mortality caused by this infection. The most vulnerable group of population for COVID–19 is also the one that has the most deficit in Vitamin D
The role of Vitamin D in the prevention of Coronavirus Disease 2019 infection and mortality DOI:10.21203/rs.3.rs-21211/v1
We review the research " Association between vitamin D deficiency and heart failure risk in the elderly " in which they reported a 12.2 times increased risk of heart failure among those with low Vitamin D levels.
Vitamin D supplements protect against severe asthma attacks. We look at the meta-analysis conducted by the Lancet which showed the possible benefits of oral vitamin D supplementation reducing the likelihood of a severe asthma attack.
Citation: Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data DOI:10.1016/S2213-2600(17)30306-5
Study: Link between vitamin D and dementia risk confirmed
- The study found that people with low levels of vitamin D had a 53-percent increased risk of developing dementia and those who were severely deficient had a 125-percent increased risk compared to participants with normal levels of vitamin D.
People with lower levels of vitamin D were nearly 70 percent more likely to develop Alzheimer's disease and those who had severe deficiency were over 120 percent more likely to develop the disease.
* August 6, 2014, online issue of Neurology
We review the study " Widespread vitamin D deficiency likely due to sunscreen use, increase of chronic diseases, review finds " in regard to sunscreen being associated with mass vitamin D deficiencies.
Citation: Vitamin D Deficiency, Its Role in Health and Disease, and Current Supplementation Recommendations. The Journal of the American Osteopathic Association, 2017; 117 (5): 301 DOI: 10.7556/jaoa.2017.055
Omega-3 fatty acids, vitamin D may control brain serotonin, affecting behavior and psychiatric disorders
- Many clinical disorders, such as autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), bipolar disorder, schizophrenia, and depression share as a unifying attribute low brain serotonin. "In this paper we explain how serotonin is a critical modulator of executive function, impulse control, sensory gating, and pro-social behavior," says Dr. Patrick. "We link serotonin production and function to vitamin D and omega-3 fatty acids, suggesting one way these important micronutrients help the brain function and affect the way we behave."
- Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar, schizophrenia, and impulsive behavior Published online before print February 24, 2015, doi: 10.1096/fj.14-268342
* Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.
